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Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis

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Whereas at earlier ages, Atp7b IEC livers exhibit regular nuclei size, no steatosis, and no inflammation, at 24 weeks of age, they develop evidence of periportal inflammatory infiltrate and cytosolic glycogenosis

These markers collectively offer a comprehensive evaluation of liver health, making them essential for monitoring therapeutic outcomes in chronic hepatitis B

ROS have a dual role: on one hand, they serve as important signaling molecules in cellular signal transduction (43), while on the other hand, excessive ROS levels may oxidize mitochondrial DNA (mtDNA) (44, 45), membrane lipids, and mitochondrial proteins (46), leading to mitochondrial structural damage and potentially accelerating functional impairment (47, 48)