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The Complete Detection Timeline and What Actually Matters Medically reviewed | Last updated: August 2025 | 10 min read The Quick Answer You're Looking For Zero Pouches View All Nicotine itself: 1-3 days Cotinine (what tests actually detect): 1-10 days for most people Heavy users: Up to 30 days in some cases Hair tests: Up to 90 days But here's what nobody's telling you: these timelines are just the beginning of the story

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4 An important takeaway is that even at its lowest nicotine level, e-cigarettes still contain the addictive substance

It prompts the body to release cholesterol and fat into the blood stream, and may lead to the development of blood clots