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Methods: This article is a Systematic Review that synthesizes recent multi-omics and clinical evidence on mechanisms (hormonal, immune-inflammatory, oxidative stress/ferroptosis, genetic/epigenetic, microbiome/metabolic) and appraises therapeutic strategies spanning surgery, hormonal suppression, assisted reproductive technologies (ART), and emerging adjuncts

Murai, T, Kawasumi, K, Tominaga, K, Okada, Y, Kobayashi, M, and T

GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

Limited human data exists, mostly anecdotal reports and case observations, and no controlled clinical trials have confirmed direct muscle growth or hypertrophy benefits

No Direct Metabolic Boost for Fat Storage : While B12 is crucial for metabolism, it doesn't directly trigger fat storage in the way, say, excess calories from food do