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The influence of reactive oxygen species in the immune system and pathogenesis of multiple sclerosis

10.1042/bj0940705 Biochem

67 In contrast to freckles (ephelides), which are commonly observed in young children with fair skin and fade in the absence of sun exposure (eg, during the winter), lentigines are persistent

Preclinical studies suggest that GLP-1 receptor activation in the brainstem can suppress sympathetic outflow and lower circulating norepinephrine levels, potentially reducing systemic vascular resistance