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Semaglutide acts on GLP-1 receptors in the brain's appetite centers, particularly the hypothalamus, to reduce hunger and increase feelings of fullness

In some individuals, the effects may resemble a condition called gastroparesis, where the stomach empties too slowly, leading to discomfort, poor appetite, or even vomiting

Modulation of GSK3 expression further confirmed its role in GLP-1s protective effects

[1] When it comes to weight loss to help with obesity, GLP-1 medications can slow digestion and increase satiety, helping you feel fuller longer and potentially reducing your overall consumption