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Semaglutide, administered once weekly at dosages ranging from 0.5 to 1 mg, showed superior efficacy compared to Dulaglutide, dosed once weekly from 0.75 to 1.5 mg, reducing both HbA1c and FBS levels

Complementary findings in dietary obesity models have also been reported, where AgRP levels were elevated under hyperphagic conditions and reduced with food restriction, while -MSH and POMC concentrations remained unchanged [60]

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The results showed a 20% lower risk of major cardiovascular events compared to the placebo group

The medication is contraindicated during pregnancy and should be discontinued at least 2 months before a planned pregnancy