Excited to share that the final chapter of my PhD thesis is now published in the Journal of Medicinal Chemistry ( Although reactivity with glutathione is commonly used as a proxy for metabolic liability of covalent drugs, in this work we show that the intrinsic reactivity (electrophilicity) of covalent warheads is not a reliable predictor of their in vivo metabolic susceptibility
Given the importance of the cofactor in energy metabolism, NAD + is especially important in mitochondrial function, and in fact both NAD + and mitochondria are concentrated in energetically demanding tissues 10,11,12
When mold spores are inhaled, they can colonize the nasal and sinus cavities
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