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Metabolic Pharmaceuticals terminated drug development in March 2007

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It is a GHRH analog, FDA-approved as Egrifta, and in its trials it reliably raised IGF-1 and dropped visceral fat in people (Falutz, NEJM 2007)

Semaglutide (Wegovy) dose ladder: 0.25mg 0.5mg 1mg 1.7mg 2.4mg (maintenance) escalating every 4 weeks Tirzepatide (Zepbound/Mounjaro) dose ladder: 2.5mg 5mg 7.5mg 10mg 12.5mg 15mg (maintenance) escalating every 4 weeks Tirzepatides longer escalation path means it may take patients slightly longer to reach full therapeutic effect, but this also allows more time for GI side effects to settle

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