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doi: 10.1016/j.neuropharm.2021.108662 106 AlvarezEMartinezMDRonceroIChowenJAGarcia-CuarteroBGispertJDet al

According to Riccardo Perfetti and colleagues from Cedars-Sinai Medical Center, Division of Endocrinology in Los Angeles, California, continuous infusion of GLP-1 to both young and old rats demonstrated an up-regulation of pancreatic-duodenum homeobox-1 (PDX-1) expression in islets and total pancreas which is essential for pancreogenesis, pancreatic cell differentiation, and maturation