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1 The gap between Mounjaro and Rybelsus for weight loss and blood sugar control is likely even larger

It does not directly target fat oxidation

The emergence of small-molecule GLP-1 agonists, such as orforglipron, which can be taken without fasting restrictions, may further reshape the competitive landscape

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For weight loss, semaglutide can lead to an average 15% weight loss in a little over a year (an average of 33 pounds in 68 weeks), according to a study in The New England Journal of Medicine