[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Peoples J.N., Saraf A., Ghazal N., Pham T.T., Kwong J.Q
[10, 11] Boosts energy The mitochondria power the cells that power you
However, drastic redistributions of MDM2 from p53 to the IGF-1R can probably only be achieved after experimental modulations, like inhibition of p53 expression by antisense strategies, etc, and do not likely occur in this manner in a physiologic context
Moreover, applying this concept to engineered broad-spectrum high-affinity reader domains such as the SH2 superbinder, which has been previously used for AP-MS (Tong et al., 2017), could identify a large fraction of tyrosine-phosphorylated proteins with spatial resolution
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