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Role of GLP-1R binding kinetics The length of time that an agonist remains bound to its receptor, or residence time, is an important factor influencing the duration of drug action and a suggested driver of sustained signaling from internalized receptors 7

W., Sun, L

Cardiovascular considerations include a small mean increase in heart rate (1-4 beats per minute) noted in clinical trials

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Rather than forcing changes through stimulants or blocking nutrient absorption, it appears to work by helping regulate the body's natural satiety mechanisms