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85% of participants Achieved an A1c of less than 7% Lost up to 10.6 kg (23.3 lbs) Improvements seen in 52 weeks Trial #5 Compared tirzepatide with placebo added to titrated insulin Glargine with or without metformin

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Common side effects include nausea, vomiting, and diarrhea, which can be managed by adjusting the dose or taking the medication with food

Abstract To assess the correlation between endothelial dysfunction and the serum levels of biomarkers of inflammation, remodelling and oxidative stress in essential hypertension, 78 treatment-nave essential hypertensives (mean age 43 years) underwent measurement of endothelial dysfunction, using the maximal acetylcholine-induced forearm vasodilation and serum levels of adhesion molecules, selectins, chemokines, metalloproteinases, copper, zinc, selenium, vitamins, homocysteine, malondialdehyde, erythrocyte glutathione peroxidase and erythrocyte superoxide dismutase

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