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Diet The details of the chemical and energy composition of the basal diet is given in Table 1

Diets rich in phytonutrients, polyphenols, and sulfur-containing compounds enhance endogenous antioxidant defenses by activating redox-sensitive transcriptional programs that support mitochondrial biogenesis, membrane integrity, and detoxification capacity

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however, oxidative stress, which is a normal process and byproduct of brain functioning, reduces this spare capacity, limiting the ability to meet heightened needs (see Supplementary Figure 2A)