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Sheweita SA, El Banna YY, Balbaa M, Abdullah IA, Hassan HE
Despite Semiglutides impressive 15.8% average weight loss in the 68-week clinical trial
These drugs induce a mean weight loss of 1.88kg and also lower blood pressure (mean: 2.46mmHg in systolic and 1.46mmHg in diastolic blood pressure).48 The EMPA-REG,49 CANVAS and CANVAS-R trials,50 conducted in patients with DM2 and high cardiovascular risk, showed empagliflozin and canagliflozin to reduce cardiovascular risk (including cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and hospital admission due to heart failure)
Beyond fat loss, Tesamorelin increases lean body mass by 1.42 kg across randomized clinical trials, improves lipid profiles (reducing triglycerides by 48 mg/dL and total cholesterol by 8 mg/dL at 52 weeks), and lowers hepatic fat fraction by 4.9% at 12 months in patients with NAFLD
