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While GLP-1 and GIP receptor activation primarily reduce energy intake through appetite suppression and delayed gastric emptying, glucagon receptor activation continues to drive energy expenditure through thermogenesis and hepatic fat oxidation regardless of whether caloric intake has already decreased

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The most important FAs in the brain and nerve system are omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

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