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GLP-1 is an incretin hormone released from intestinal L-cells after nutrient intake, and it acts on GLP-1 receptors distributed across pancreatic tissue, the central nervous system, and the gastrointestinal tract

It is a triple agonist that activates three receptors simultaneously: GIP, GLP-1, and glucagon

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A top-tier review of gut microbiota in metabolic health describes how community composition and microbial metabolites SCFAs among them mediate the relationship between the microbiome and host metabolism