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It is a suitable option when diet and exercise alone are not enough to control blood sugar

When comparing the results from the current dose escalation experiment in DIO Wistar rats to those from our earlier experiments performed with lean rats 16 , and found that GEP44 treatment results in comparable anorectic effects in both models

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[174] An observational study on people with obesity and type 2 diabetes and heart failure with preserved ejection fraction, semaglutide had about a 42% lower risk of hospitalization for heart failure and all-cause death combined compared with sitagliptin

Consider dose adjustment : If taste changes are severe, your prescriber may recommend temporarily reducing the dose before re-escalating more gradually