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Pharmacokinetic modeling in swine confirmed dose-dependent GH release with an ED50 of 2.3 nmol/kg and Emax of 65 ng GH/mL plasma (Johansen et al., 1999)

We have also shown that GH-induced insulin resistance is associated with suppressed pyruvate dehydrogenase activity in skeletal muscle (101)

Not because they stop ageing, but because they each intervene in processes that are strongly linked in science to healthy ageing: NAD metabolism, methylation, mitochondrial energy, oxidative stress, and glutathione production

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