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Pathway level effects reported are changes in kinase mediated signal transduction activity, transcriptional activity related to matrix deposition and control of factors associated with cellular migration and adhesion
The iron addiction of tumor cells determines that the iron demand is more than that of healthy cells, which leads to cell death due to ferroptosis, mainly depending on the accumulation of iron ions, the metabolism of lipid peroxides and the regulation of related enzymes [33]
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Reaching steady state sooner has the potential benefit of reaching therapeutic levels more quickly, and reaching washout sooner has the potential benefit of getting rid of adverse effects more quickly
K., Dorr, R.T
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