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Free Radic Biol Med 182:206218

MSG increased the oxidative stress that leads to kidney tissue and function damage via several mechanisms including: (1) reduced activities of some antioxidant enzymes as catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) and glutathione (GSH) and increased MDA level in the kidney, (2) increased activity of -ketoglutarate dehydrogenase, a potential ROS generator, (3) enhanced free radical generation through increased intracellular calcium level, and (4) decreased GSH levels that may increase ROS-induced renal cell damage [12, 14, 60]

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In sum, we did not detect a clear sex difference in the effect of NR1 gene knock-out in any of the analyses in Figure 9

Its important to highlight that CJC 1295 isnt a one-size-fits-all solution, and its use should be closely monitored by a healthcare professional