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Kastenmller are co-inventors (through Duke University/Helmholtz Zentrum Mnchen) on patents on applications of metabolomics in diseases of the central nervous system and hold equity in Chymia LLC and IP in PsyProtix and Atai that are exploring the potential for therapeutic applications targeting mitochondrial metabolism in treatment-resistant depression

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Moreover, small prospective trials demonstrated that metformin reduces left ventricular (LV) mass and improves diastolic function and myocardial energetics, suggesting favorable effects on cardiac remodeling central to DCM pathophysiology (Mohan et al., 2019)