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However, due to the lack of long-term observation of GSH depletion and in vivo animal experiments, it is difficult to evaluate whether ferroptosis is a bona fide autophagy activation process or a prerequisite for autophagy activation process

Each of these proteins has been found to be overactive in different types of cancer

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Cardiovascular outcomes (TRIUMPH-Outcomes results expected 20282029) Cancer risk (very long-term monitoring needed) Effects in special populations (elderly, multiple comorbidities) Reassurance: Phase 2 participants stopping medication in extension showed reversibility of side effects, including dysesthesia