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The survival of SGNs is essential for hearing preservation and, conversely, as SGN cannot regenerate spontaneously, the impairment and irreversible loss of SGNs result in permanent sensorineural hearing loss (SNHL) ( Studies have shown that organisms can activate a series of defense responses, such as improving the activity of antioxidant enzymes in the body and initiating lysosomal degradation pathways, to prevent oxidative damage

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J Invest Dermatol 142:1824-1834.e7

Patients with depression carrying the D/D variant of the ACE gene show considerably greater activation of the HPA axis (65)

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