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DSIP is investigated primarily in the context of sleep architecture regulation, stress-induced neuroendocrine modulation, and hypothalamic-pituitary-adrenal (HPA) axis signaling

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Current Biology , 31 (4), 753765e756

Interestingly, GHK alone appeared to produce a comparable stimulatory action, while copper(II) ions in isolation may indicate no such activity, suggesting the tripeptide moiety may be the primary active component, possibly reforming complexes with trace copper present in the culture medium