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MC4R, appetite and sexual function MC4R is the main regulator of energy balance in the hypothalamus (particularly in the PVN, paraventricular nucleus)

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In the archival RISK dataset, we found mevalonate, fatty acid, and uridine metabolism to be altered, while in enteroids, we found glycerophospholipid, linoleic acid, and sphingolipid metabolism to be altered (Figs