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Effectiveness and safety of once-weekly semaglutide in Japanese patients with type 2 diabetes in treatment intensification: a retrospective observational single-center study

The lack of cortisol stimulation is particularly advantageous, as chronic cortisol elevation can lead to numerous adverse effects including immune suppression, bone loss, and metabolic dysfunction

doi:10.1016/j.jamda.2013.03.022

After subcutaneous injection, the plasma concentration of semaglutide gradually increased, reaching maximum concentrations in 312 h, and then decreased with an average t 1/2 of 7.228.99 h, with peak concentrations of 24,943.33 1087.19 and 27,636.5 2331.98 ng/mL, respectively