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Though the absolute risk of GLP-1 related aspiration during intubation is still low, case studies of large volume emesis in patients who fasted 20 hours have been concerning enough to prompt the American Society of Anesthesiology to issue a guidance suggesting holding GLP-1 agonists prior to elective intubations4,5

Instead, many are becoming more intentional

Recent studies evaluating the co-administration of SGLT2 inhibitors with other classes of drugs have shown promising results

As a GIP/GLP-1 receptor agonist, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

T.ZhangQ.WitleyS.Blid SkoldhedenS.et al