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The role of zebrafish in nicotine medicinal research To determine the medical benefits and side effects of nicotine and other tobacco derivatives intense research and analysis are needed, compiling basic research, efficacy assays, toxicity assays nd clinical trials

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[4] This blood clot is replaced with granulation tissue which consists of proliferating fibroblasts and endothelial cells derived from remnants of the periodontal membrane, surrounding alveolar bone and gingival mucosa