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Although the structure of the intestinal microbiota is very complex and the experimental design varies among studies, such as the different timing of HFD induction, distinctions in the duration of metformin treatment, and variations in mouse strains, but the impact of metformin on gut microbiota derived from these studies are nearly consistent
Together, these results suggest that intestinal IL-22 signaling maintains glucose homeostasis and metabolic function, at least in part through its action on GLP-1
Humans endogenously produce 1.2 mol/kg of body weight of carnitine on a daily basis, accounting for 25% of the carnitine in the body
Regarding tolerability, evidence indicates that GLP-1RAs are safe for non-diabetic obese patients
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