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Surgery 159 , 14221429 (2016)

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Other cellular factors such as oxidative stress and inflammation can also negatively impact systemic and cerebral endothelial function by damaging endothelial cells (Shaito et al., 2022) and reducing nitric oxide bioavailability (Gryglewski et al., 1986)

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The therapy builds on its earlier 2022 approval for moderate-to-severe Plaque Psoriasis, strengthening the companys strategy to expand an oral immunology franchise across multiple inflammatory conditions