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Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful ageing

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Large doses of vitamin A over a short period lead to whats called chronic retinoid toxicity, which can have major effects on multiple organ systems

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The first step in the synthesis of GSH is the formation of -glutamyl-cysteine (GluCys) from the constituent amino acids glutamate and cysteine by the enzyme -glutamyl-cysteine synthetase (GCS, also called glutamate cysteine ligase (GCL))