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SGLT-2 inhibitors retain adjunctive roles, often combined for cardiorenal protection, while amylin analogues remain niche given specificity to postprandial control

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Acknowledgements We thank BioRender software for assistance with the creation of Fig

In ambient air and under regular growth conditions, many photorespiratory mutants exhibit compromised photosynthesis and growth, phenotypes that are largely recovered under high CO 2 environments where rubisco oxygenation is inhibited 8,9