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Adequate B12 status is necessary for normal cellular function, but supraphysiological dosesbeyond correcting deficiencydo not demonstrably enhance metabolism in individuals with normal B12 levels

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However, further retrospective case series have identified liver injury and hepatotoxicity in children following paracetamol intoxication, particularly following multiple sequential overdoses , and that the mortality in these cases can be high

10.1016/j.freeradbiomed.2018.03.001 29 GanT.WangQ.SongY.ShaoM.ZhaoY.GuoF.et al (2024)