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Clinical Update 2/02/2024 Lower Blood Sugar with Aloe

Regarding the role of GLP-1 RA in heart failure, some older trials did not show benefits in patients with HFrEF

Animal studies used oral doses of 550mg/kg to compensate for low bioavailability and first-pass metabolism

Companies developing and producing GLP-1 drugs include Novo Nordisk and Eli Lilly

Based on the current MHRA-approved SmPC for injectable tirzepatide (Mounjaro), the following guidance would likely apply to any future oral formulation, though specific contraindications may differ if such a product is eventually authorised