GLP-1R mRNA and GLP-1 immunoreactivity was detected in the VTA and NAc, as well as other reward associated areas including lateral hypothalamus, lateral habenula, hippocampus, and substantia nigra (Merchenthaler et al., Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain
FDA prescribing information for these medications includes warnings about the risk of acute kidney injury in patients who experience severe adverse gastrointestinal reactions
doi: 10.1007/s00280-020-04092-2 74 GalonJMlecnikBBindeaGAngellHKBergerALagorceCet al
[ Links ] Gonzlez-Trujano ME, Alvarado-Vsquez N, Mendoza-Sotelo J, Lpez G, Estrada-Camarena E, Martnez-Mota L, Moreno J (2012)
Recommended products Receptor Activity Retatrutide GLP-1 GIP Glucagon Tirzepatide GLP-1 GIP The addition of glucagon receptor activation gives Retatrutide a broader biological profile for scientific investigation
