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114 The density of AMPA, NMDA and P2X receptors as well as the density of plasmalemmal glutamate transporter currents demonstrates bell-shaped age dependency, with maximal densities observed in adult animals, whereas ageing is accompanied by a 2-3 fold decrease of density of respective ion currents

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Informed by Robust Clinical Literature : Phase 1b, phase 2, and phase 3a programs have generated substantial data in obesity and type 2 diabetes research populations, helping guide mechanistic and translational study design