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Steve Schow and James Keck for their insightful comments and Ms

Akkermansia muciniphila supplementation has been shown to reduce BP through the reduction of OS markers, likely through increased propionate production, but its translation to the clinic is quite controversial (Lakshmanan et al., 2022)

Little to no weight change initially: Significant weight loss typically becomes more evident from weeks four to eight onwards, as the dose is increased and the body responds to sustained appetite reduction

Cryo-EM imaging was performed on a Titan Krios at 300 kV accelerating voltage in the Center of Cryo-Electron Microscopy Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Shanghai, China)

Do a patch test before full application