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The ones who benefit most are those with elevated baseline ALT, visible hepatic steatosis on imaging, or mid-afternoon fatigue that doesn't resolve with caffeine

Therefore, a more inclusive strategy involves examining metabolic syndrome, a collection of conditions such as central obesity, hypertension, hyperlipidemia, and diabetes, as a comprehensive risk profile ( Numerous epidemiological studies have investigated the association between diabetes mellitus (DM) and Alzheimer's disease (AD), with a significant body of evidence indicating a direct connection between Type 2 Diabetes (T2D) and an elevated risk of developing AD

They can be incredibly helpful when used appropriately

doi: 10.2174/1381612823666170622110046

doi: 10.2174/157015908787386069