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But it may not be a bad thing

No returns due to regulations

Indeed, despite significant adaptations during the transition between DS and PS, as well as during the first deterministic and probabilistic sessions (14), the animals behavior at the end of each setting is overall stable, and the choice behavior close to steady-state

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Note: The relative risk evoked here is evaluated against a reference cigarette, 3R4F developed by PMI: The assessments for the 3R4F cigarette by smoking regimen found as a trivial effect, due to the higher amount of smoke generated per cigarette under HCI conditions, an increased yield of toxicant and higher toxicological activity per cigarette. An interesting aspect of the relative risk evaluation should arise from the comparison of THS 2.2 with regular vaping devices, for example