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Bmal1 knockout mice display lower blood pressure and abolished rhythmicity (Curtis et al., 2007), whereas Per1 has been implicated in aldosterone (Richards et al., 2013) and sodium regulation (Stow et al., 2012), both of which play a role in blood pressure maintenance

Among them, the glutathione system made up of GSH, enzymes involved in GSH anabolism, and GSH-dependent antioxidant enzymes play a critical role in cardioprotection from oxidative stress and redox homeostasis [12,13,14]

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Nausea, vomiting, diarrhea, and constipation affected 60 to 80% of participants at higher doses, though most symptoms were mild to moderate in severity

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children