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Mechanistically, as reported here for miR-4488, some other rRFs have been shown to associate with Argonaute proteins, promoting silencing of gene expression (Li et al, 2012

Cleft lip and the combination of cleft lip and cleft palate occur twice as often in males as in females, while cleft palate alone occurs more often in females

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(2003) onlinelibrary.wiley.com From the publication: Total testosterone Each subject in both the old and young groups showed a marked diurnal variation in serum total testosterone, with a minimum decrease (peak to nadir) of 43% of the peak value