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Paxillin is a major phosphotyrosine-containing protein during embryonic development

Results of previous studies on topical gel formulation of hydroquinone-loaded SLNs indicated a significantly higher drug deposition within the epidermis layer (46.5% 2.6%) in comparison to the conventional gel of hydroquinone (15.1% 1.8%) ( in vitro permeation study on rat skin revealed that drug accumulation within the skin layers was approximately 3 times higher, while the drug flux into the receptor phase of Franz cells was about 6.5 times lower in hydroquinone-loaded SLNs in comparison to the hydroquinone gels which confirmed the reduced systemic absorption and further reduced adverse drug reactions through the encapsulation in SLNs (Wu et al., 2017)

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These are generally mild to moderate and tend to improve as the body adjusts to each dose escalation step

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