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Further, in vitro evidence (72) shows that urolithin A and its phase-II metabolites can cross the bloodbrain barrier, an ability that would be necessary for their direct effects in the brain

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The GSH and NO levels observed in the systemic compartment in ALS patients during disease progression lends further credence to the idea that oxidative stress is an important hallmark of the pathological changes in ALS

doi: 10.1016/0273-1177(94)90333-6 58 National Academies of Sciences and Medicine (2023)