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According to NICE guidance, hydroxocobalamin injections are the recommended first-line treatment for pernicious anaemia and other malabsorption-related deficiencies

however, data regarding prevalence is lacking and varies greatly between countries

Extracted data from the final selection of articles were then narratively synthesized to delineate the current state of knowledge and identify existing gaps in the literature

Studies examining asthma, COPD and CF have focused on the role of the immune system [3,4,5,6,7] and epithelial ion channels in mucus secretion [8,9,10,11,12], but the involvement of the nervous system, and in particular neuropeptide signaling, remains a field of much unknowns [13]

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