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Studies have shown that the rs822336 SNP in the PD-L1 promoter/enhancer region affects PD-L1 expression by competing for binding sites with the transcription factors C/EBP (CCAAT-enhancer-binding protein beta) and NFIC (nuclear factor I C)

In a clinical trial, TB4 at a dose of 0.03% applied topically to venous ulcers led to complete wound healing in 33.3% of patients, compared to 23.5% for placebo

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By exerting these effects, BPC 157 fosters an environment conducive to tissue repair, thereby accelerating the healing process