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Description

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Coronary atherosclerosis initiates with endothelial damage to the vascular intima, followed by a sequence of events including lipid deposition, vascular smooth muscle cell proliferation, and extracellular matrix synthesis, collectively resulting in arterial wall thickening and progressive luminal narrowing (17)

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The mechanism: cagrilintide is an amylin analogue that delays gastric emptying and suppresses glucagon secretion, with peak plasma concentration occurring 90-120 minutes post-injection

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