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[DOI] [PubMed] [Google Scholar] 56.Rebouche C.J

Here is what a physician-guided transition plan looks like: Stabilize at goal weight for at least 36 months before beginning a taper this confirms your habits are working, not just the medication Gradual dose reduction rather than abrupt cessation typically stepping down over 23 months to allow appetite to readjust slowly Protein targets remain non-negotiable maintaining 1.21.6g/kg/day is the single most evidence-supported dietary habit for weight maintenance Resistance exercise at least 23 times per week muscle mass is your metabolic insurance policy after stopping Regular physician check-ins monthly weight and metabolic monitoring during and after tapering catches any concerning regain early Clear re-engagement plan agree in advance with your physician on the weight threshold that would prompt restarting medication Frequently Asked Questions Can I take semaglutide indefinitely

MASH resolution: The trial measured this at 72 weeks

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Seek urgent care for trouble breathing, swelling of the face or throat, severe hives, fainting, confusion, repeated vomiting, signs of severe dehydration, or intense abdominal pain