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Awasthi YC

From this research, then consolidated over time [23,48], it emerged that the brain, under chronic stress, undergoes functional and structural alterations, with atrophy of the mPFC, the hippocampus and a hypertrophy of the orbitofrontal, while the amygdala seems to undergo a contrasting alteration: hypertrophy of the basolateral nucleus and hypotrophy of the central nucleus

Minimal impact beyond melatonin restoration

Control rats exhibited preserved ultrastructural integrity, characterized by axonal terminals with intact membranes without swelling, mitochondria displaying organized cristae and intact membranes (Fig