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Finally, we also examined the capacity of each mutant to recruit GRK2, a GPCR kinase known to be recruited to active GLP-1R and to regulate GLP-1R-mediated secretory responses in -cells (20)

Hepatoma cell lines, such as HepG2, in general display lower expression levels of hepatic phase I and phase II enzymes compared with primary hepatocytes, thus questioning their informative value for the situation in vivo

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It also tended to have more unpleasant side effects